Reduced but not oxidized cerebrospinal fluid glutathione levels are lowered in Lewy body diseases
Identifieur interne : 001429 ( Main/Exploration ); précédent : 001428; suivant : 001430Reduced but not oxidized cerebrospinal fluid glutathione levels are lowered in Lewy body diseases
Auteurs : Walter Maetzler [Allemagne] ; Stefan P. Schmid [Allemagne] ; Isabel Wurster [Allemagne] ; Inga Liepelt [Allemagne] ; Alexandra Gaenslen [Allemagne] ; Thomas Gasser [Allemagne] ; Daniela Berg [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-01.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Cerebrospinal fluid, Dementia (blood), Dementia (cerebrospinal fluid), Female, Glutathione, Glutathione (blood), Glutathione (cerebrospinal fluid), Glutathione Disulfide (blood), Glutathione Disulfide (cerebrospinal fluid), Humans, Lewy Body Disease (blood), Lewy Body Disease (cerebrospinal fluid), Lewy body dementia, Lewy body disease, Male, Middle Aged, Nervous system diseases, Parkinson Disease (blood), Parkinson Disease (cerebrospinal fluid), Parkinson disease, Parkinson's disease, age dependency, dementia with Lewy bodies, glutathione.
- MESH :
- chemical , blood : Glutathione, Glutathione Disulfide.
- blood : Dementia, Lewy Body Disease, Parkinson Disease.
- cerebrospinal fluid : Dementia, Glutathione, Glutathione Disulfide, Lewy Body Disease, Parkinson Disease.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged.
Abstract
Reduced (GSHR) but not oxidized glutathione (GSSG) has been shown to be dramatically altered in the substantia nigra (SN) of Lewy body disease (LBD) patients post mortem; but up to now, there is no convincing evidence that these changes can be monitored in vivo. We investigated GSHR and GSSG in rapidly processed cerebrospinal fluid (CSF) and plasma samples of 80 LBD and 35 control subjects and detected reduced CSF GSHR levels in LBD subjects. The reduction was negatively associated with age but not with disease‐associated parameters. Plasma GSHR, CSF GSSG, and plasma GSSG levels did not significantly differ between the groups. Our findings confirm the results from neuropathologic studies, which demonstrated an alteration of the glutathione system in LBD. We hypothesize that alterations of the glutathione system occur in a very early stage of the disease or may even represent a risk marker for LBD. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23358
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000D53
- to stream Istex, to step Curation: 000D53
- to stream Istex, to step Checkpoint: 000161
- to stream PubMed, to step Corpus: 001551
- to stream PubMed, to step Curation: 001551
- to stream PubMed, to step Checkpoint: 001123
- to stream Ncbi, to step Merge: 002E66
- to stream Ncbi, to step Curation: 002E66
- to stream Ncbi, to step Checkpoint: 002E66
- to stream Main, to step Merge: 001482
- to stream PascalFrancis, to step Corpus: 000724
- to stream PascalFrancis, to step Curation: 002594
- to stream PascalFrancis, to step Checkpoint: 000423
- to stream Main, to step Merge: 001A13
- to stream Main, to step Curation: 001429
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Reduced but not oxidized cerebrospinal fluid glutathione levels are lowered in Lewy body diseases</title><author><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name></author><author><name sortKey="Schmid, Stefan P" sort="Schmid, Stefan P" uniqKey="Schmid S" first="Stefan P." last="Schmid">Stefan P. Schmid</name></author><author><name sortKey="Wurster, Isabel" sort="Wurster, Isabel" uniqKey="Wurster I" first="Isabel" last="Wurster">Isabel Wurster</name></author><author><name sortKey="Liepelt, Inga" sort="Liepelt, Inga" uniqKey="Liepelt I" first="Inga" last="Liepelt">Inga Liepelt</name></author><author><name sortKey="Gaenslen, Alexandra" sort="Gaenslen, Alexandra" uniqKey="Gaenslen A" first="Alexandra" last="Gaenslen">Alexandra Gaenslen</name></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5BBD2155C3DE47FABF651B9EB5344D9AB405135C</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23358</idno><idno type="url">https://api.istex.fr/document/5BBD2155C3DE47FABF651B9EB5344D9AB405135C/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000D53</idno><idno type="wicri:Area/Istex/Curation">000D53</idno><idno type="wicri:Area/Istex/Checkpoint">000161</idno><idno type="wicri:doubleKey">0885-3185:2011:Maetzler W:reduced:but:not</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:20842692</idno><idno type="wicri:Area/PubMed/Corpus">001551</idno><idno type="wicri:Area/PubMed/Curation">001551</idno><idno type="wicri:Area/PubMed/Checkpoint">001123</idno><idno type="wicri:Area/Ncbi/Merge">002E66</idno><idno type="wicri:Area/Ncbi/Curation">002E66</idno><idno type="wicri:Area/Ncbi/Checkpoint">002E66</idno><idno type="wicri:Area/Main/Merge">001482</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:11-0143239</idno><idno type="wicri:Area/PascalFrancis/Corpus">000724</idno><idno type="wicri:Area/PascalFrancis/Curation">002594</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000423</idno><idno type="wicri:doubleKey">0885-3185:2011:Maetzler W:reduced:but:not</idno><idno type="wicri:Area/Main/Merge">001A13</idno><idno type="wicri:Area/Main/Curation">001429</idno><idno type="wicri:Area/Main/Exploration">001429</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Reduced but not oxidized cerebrospinal fluid glutathione levels are lowered in Lewy body diseases</title><author><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Geriatric Rehabilitation, Robert‐Bosch‐Hospital, Stuttgart</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation></author><author><name sortKey="Schmid, Stefan P" sort="Schmid, Stefan P" uniqKey="Schmid S" first="Stefan P." last="Schmid">Stefan P. Schmid</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Wurster, Isabel" sort="Wurster, Isabel" uniqKey="Wurster I" first="Isabel" last="Wurster">Isabel Wurster</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Liepelt, Inga" sort="Liepelt, Inga" uniqKey="Liepelt I" first="Inga" last="Liepelt">Inga Liepelt</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Gaenslen, Alexandra" sort="Gaenslen, Alexandra" uniqKey="Gaenslen A" first="Alexandra" last="Gaenslen">Alexandra Gaenslen</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-01">2011-01</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="176">176</biblScope><biblScope unit="page" to="181">181</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5BBD2155C3DE47FABF651B9EB5344D9AB405135C</idno><idno type="DOI">10.1002/mds.23358</idno><idno type="ArticleID">MDS23358</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cerebrospinal fluid</term><term>Dementia (blood)</term><term>Dementia (cerebrospinal fluid)</term><term>Female</term><term>Glutathione</term><term>Glutathione (blood)</term><term>Glutathione (cerebrospinal fluid)</term><term>Glutathione Disulfide (blood)</term><term>Glutathione Disulfide (cerebrospinal fluid)</term><term>Humans</term><term>Lewy Body Disease (blood)</term><term>Lewy Body Disease (cerebrospinal fluid)</term><term>Lewy body dementia</term><term>Lewy body disease</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (cerebrospinal fluid)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>age dependency</term><term>dementia with Lewy bodies</term><term>glutathione</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Glutathione</term><term>Glutathione Disulfide</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Dementia</term><term>Lewy Body Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Dementia</term><term>Glutathione</term><term>Glutathione Disulfide</term><term>Lewy Body Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Corps Lewy maladie</term><term>Démence à corps de Lewy</term><term>Glutathion</term><term>Liquide céphalorachidien</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Reduced (GSHR) but not oxidized glutathione (GSSG) has been shown to be dramatically altered in the substantia nigra (SN) of Lewy body disease (LBD) patients post mortem; but up to now, there is no convincing evidence that these changes can be monitored in vivo. We investigated GSHR and GSSG in rapidly processed cerebrospinal fluid (CSF) and plasma samples of 80 LBD and 35 control subjects and detected reduced CSF GSHR levels in LBD subjects. The reduction was negatively associated with age but not with disease‐associated parameters. Plasma GSHR, CSF GSSG, and plasma GSSG levels did not significantly differ between the groups. Our findings confirm the results from neuropathologic studies, which demonstrated an alteration of the glutathione system in LBD. We hypothesize that alterations of the glutathione system occur in a very early stage of the disease or may even represent a risk marker for LBD. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Stuttgart</li><li>District de Tübingen</li></region><settlement><li>Stuttgart</li><li>Tübingen</li></settlement></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name></region><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><name sortKey="Gaenslen, Alexandra" sort="Gaenslen, Alexandra" uniqKey="Gaenslen A" first="Alexandra" last="Gaenslen">Alexandra Gaenslen</name><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><name sortKey="Liepelt, Inga" sort="Liepelt, Inga" uniqKey="Liepelt I" first="Inga" last="Liepelt">Inga Liepelt</name><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><name sortKey="Schmid, Stefan P" sort="Schmid, Stefan P" uniqKey="Schmid S" first="Stefan P." last="Schmid">Stefan P. Schmid</name><name sortKey="Wurster, Isabel" sort="Wurster, Isabel" uniqKey="Wurster I" first="Isabel" last="Wurster">Isabel Wurster</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001429 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001429 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:5BBD2155C3DE47FABF651B9EB5344D9AB405135C
|texte= Reduced but not oxidized cerebrospinal fluid glutathione levels are lowered in Lewy body diseases
}}
| This area was generated with Dilib version V0.6.23. |  |